Accession Number:

ADA334893

Title:

Function of Cell Cycle Control Proteins in Breast Cancer.

Descriptive Note:

Annual rept. 1 Aug 96-31 Jul 97,

Corporate Author:

HARVARD MEDICAL SCHOOL BOSTON MA

Personal Author(s):

• Hinds, Phillip W.

Report Date:

1997-09-01

Pagination or Media Count:

67.0

Abstract:

Loss of the retinoblastoma tumor suppressor protein pRb can contribute to breast tumor formation. However, many breast tumors retain expression of normal pRb, indicating that other genetic events may interfere with the function of this growth regulatory protein. Overexpression of cyclin Dl is such an event, since high levels of this protein may lead to constitutive inactivation of pRb through phosphorylation.

Descriptors:

• *PROTEINS
• *CELLS(BIOLOGY)
• *BREAST CANCER
• NEOPLASMS
• CYCLES
• RETINA
• GENETICS
• TRANSFORMATIONS
• MAMMARY GLANDS
• SUPPRESSORS
• PHOSPHORYLATION

Subject Categories:

• Biochemistry
• Genetic Engineering and Molecular Biology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE