Accession Number:

ADA334783

Title:

Breast Tumorigenesis: Interaction of Two Signaling Pathways- -TGF- -beta versus Estrogen Receptor.

Descriptive Note:

Final rept. 1 Sep 94-31 Aug 97

Corporate Author:

DUKE UNIV DURHAM NC

Personal Author(s):

Report Date:

1997-08-01

Pagination or Media Count:

52.0

Abstract:

The overall goal of this research project is to explore the roles of TGF-Beta and components of its signaling pathways in the initiation, progression and metastasis of breast adenocarcinomas through an investigation of the disregulation of TGF-Beta signal transduction. Last year, we identified and isolated three cDNAs encoding members of the Smad family and studied the TGF-Beta induced phosphorylation of these molecules in a normal mammary epithelial cell line. Subsequently, we have focused on the functional role of Smad3 and Smad4 as tumor suppressors in mediating the TGF-Beta signal in transactivating downstream target genes. We have extended our analysis of the biological activity of the Smad proteins in TGF-Beta signaling by studying the nuclear activity of Smad2, Smad3 and Smad4. Results from further analysis in these directions will not only significantly contribute to an understanding of the molecular events leading to breast carcinogenesis, but also aid in the development of new therapeutics for breast cancer.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE