Accession Number:

ADA334733

Title:

Relationships of Blood and Brain Halocarbon Solvent Concentrations to Neurobehavioral Toxicity

Descriptive Note:

Final rept

Corporate Author:

AIR FORCE RESEARCH LAB BOLLING AFB DC

Personal Author(s):

• Warren, David A.

Report Date:

1995-01-01

Pagination or Media Count:

127.0

Abstract:

Time-courses of blood and brain concentrations and neurobehavioral toxicity were determined for two halocarbon solvents in two rodent species. Based on these data, quantitative relationships, or the lack thereof, have been reported between the degree of neurobehavioral toxicity and internal measures of dose. In the case of orally- administered perchloroethylene PCE, relationships between blood and brain concentrations and operant performance were not discernable, due in part to an acute adaptation of rats to PCEs response suppressing effect. For inhaled 1,1,1- trichloroethane TRI, blood and brain concentrations were strongly correlated with the rate of operant responding in rats.

Descriptors:

• *TOXICITY
• *BEHAVIOR
• *NEUROBIOLOGY
• BRAIN
• RATS
• THESES
• CARBON
• DOSAGE
• SOLVENTS
• PHARMACOKINETICS
• HALOGENATED HYDROCARBONS
• CONCENTRATION(CHEMISTRY)
• BLOOD
• CHLORINATED HYDROCARBONS
• TRICHLOROETHANES
• EXTRAPOLATION

Subject Categories:

• Toxicology
• Organic Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE