Accession Number:

ADA334721

Title:

Interaction of Light and Clock Regulation in Neurospora

Descriptive Note:

Final rept 1 Jun 94-30 Sep ,97

Corporate Author:

DARTMOUTH MEDICAL SCHOOL HANOVER NH DEPT OF PHARMACOLOGY AND TOXICOLOGY

Personal Author(s):

Report Date:

1997-09-01

Pagination or Media Count:

11.0

Abstract:

Interest is focused on understanding the molecular mechanisms involved in how eukaryotic cells and organisms keep time on a daily basis and how visible light entrains the clock mechanism at the molecular level Seminars in the Neurosciences, 7 3-13, 1995. In the model organism, Neurospora crassa, ambient light has been shown to act either independently of, or coordinately through the circadian pacemaker. Significant advances in our understanding of how light effects a single component of the clock and thereby results in entrainment of clock phase has been made by examinaion of light effects on the frequency locus transcript, a known component of the I clock Cell 81, 1003 - 1012, 1995. Analysis of clock-output genes find them involved in a diverse set of cell functions, photo-inducibility to be clock independent. Promoter resection analysis shows sequences necessary and sufficient for clock-independent light regulation.

Subject Categories:

  • Biochemistry
  • Genetic Engineering and Molecular Biology
  • Biology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE