Suppression of Lymphocyte Signal Transduction by Oxygen Intermediates
Annual rept 30 Sep 96-29 Sep 97
NEW YORK UNIV MEDICAL CENTER TUXEDO NY
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Effects of different types of oxidative stress OS on cellular anti-oxidant mechanisms were compared. Human blood lymphocytes were subjected to a. Acute exposure to H2O2 b. Chronic exposure to H2O2 c. Ionizing radiation. Enhanced catalase activity was detected in human peripheral blood T lymphocytes exposed to oxidative stress. Glutathione peroxidase activity and reduced glutathione, vitamin C and vitamin E levels, were not modulated by oxidative stress. Only exposure to hydrogen peroxide at 20 micrometer did not enhance catalase activity in T lymphocytes.
- Medicine and Medical Research