Regulation of GnRH Receptor mRNA: Interaction of GnRH and Estradol.
COLORADO STATE UNIV FORT COLLINS
Pagination or Media Count:
The integrated functions of the hypothalamus, anterior pituitary gland, and ovaries serve to regulate normal female reproductive function. The hypothalamus secretes Gonadotropin-Releasing Hormone GnRH, a peptide hormone, in a pulsatile manner. GnRH stimulates the anterior pituitary gland via binding to specific, high-affinity receptors on the plasma membrane of gonadotrophs. GnRH binding initiates a cascade of intracellular events resulting in synthesis and secretion of the gonadotropins, luteinizing hormone LH and follicle-stimulating hormone FSH, and also synthesis and insertion of its own receptors into the plasma membrane. When gonadotropins are released into circulation, they exert their primary biological effects at the gonads. Ovarian hormones, progesterone, inhibin, and estradiol, feedback effects at both the hypothalamus and pituitary gland. Progesterone reduces the pulse frequency and amplitude of GnRH being released from the hypothalamus, thus, decreasing gonadotropin secretion. It is important to note that estradiol does not stimulate secretion of gonadotropins into the circulation. Inhibin is a direct regulator of FSH synthesis and secretion.
- *RIBONUCLEIC ACIDS
- INTEGRATED SYSTEMS
- PITUITARY GLAND
- SEX GLANDS
- Medicine and Medical Research