Mdm2 Function in Tumorigenesis.
Annual rept. 1 Sep 96-31 Aug 97
TEXAS UNIV AT HOUSTON
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To examine mdm2 function in vivo, we have performed experiments in two mouse models. The mdm2 null mouse is an embryo lethal whose phenotype is completely rescued in the absence of p53. We have assayed the importance of p21 as a p53 target in this system and find that it is irrelevant. The mdm2 null phenotype is not affected by loss of p21. In addition, we have analyzed transgenic mice that overexpress mdm2 in the breast epithelium and find that the mammary epithelial cells undergo multiple rounds of DNA synthesis without cell division. Importantly, this phenomenon is independent of p53 suggesting novel functions for MDM2.
- Medicine and Medical Research