Receptors, Afferent Signaling and Central Integration in Compensated and Uncompensated Hemorrhagic Shock.
Annual progress rept. 1 Jan-31 Dec 97,
IOWA UNIV IOWA CITY
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To examine the mechanisms by which melanopeptides and hypertonic saline activate pressor mechanisms during hemorrhagic shock. Approach Hemorrhagic shock is induced in rats by the controlled withdrawal of specific blood volumes, graded by body weight. Mean arterial pressure MAP and heart rate HR serve as indices of cardiovascular flinction, and ultimately as indicators of hemorrhage-induced shock. In this model of hemorrhagic shock, the melanopeptide, y-MSH, is administered peripherally or centrally, post-hemorrhage, to determine the therapeutic potential of the compound in treating hemorrhagic shock. The ability of y-MSH and hypertonic saline to increase survivability under the condition of hemorrhagic shock is being evaluated.
- Medicine and Medical Research