Accession Number:

ADA331171

Title:

Human Breast Cancer Cell Proliferation and Modulation by Melatonin and Environmental Magnetic Fields

Descriptive Note:

Final rept. 1 Jul 94-30 Apr 97

Corporate Author:

CALIFORNIA UNIV BERKELEY LAWRENCE BERKELEY LAB

Personal Author(s):

• Liburdy, Robert P.

Report Date:

1997-05-01

Pagination or Media Count:

73.0

Abstract:

The overall purpose of this study is to investigate the role that environmental-level magnetic fields may play as an exogenous factor in the etiology of human breast cancer. During this two-year research period significant progress has been made. We have observed that a the hormone melatonin and drug tamoxifen, which both inhibit human breast cancer cell growth, are each blocked or inhibited by environmental-level 12 mG 60Hz magnetic fields b this effect is observed at physiological levels of melatonin and pharmacological levels of tamoxifen c an exposure dose-response exists between 2-12 mG for melatonin d exposure duration data indicates field treatment is required for at least one cell cycle e the magnetic field not the electric field is the operative field metric and f frequency dependency experiments suggest this interaction is consistent with relatively long times of milliseconds implicating slow biological based processes.

Descriptors:

• *MAGNETIC FIELDS
• *HUMANS
• *MELATONIN
• *BREAST CANCER
• HORMONES
• ENVIRONMENTS
• RISK
• IN VITRO ANALYSIS
• ETIOLOGY
• PHYSIOLOGY
• EXPOSURE(PHYSIOLOGY)
• RESPONSE(BIOLOGY)
• CELLS(BIOLOGY)
• PHARMACOLOGY
• GROWTH(PHYSIOLOGY)

Subject Categories:

• Biochemistry
• Medicine and Medical Research
• Pharmacology
• Electricity and Magnetism

Distribution Statement:

APPROVED FOR PUBLIC RELEASE