Accession Number:

ADA330068

Title:

Effects of Almitrine Bismesylate in a Microswine Model of Hypoxemic Hypothermia

Descriptive Note:

Journal article

Corporate Author:

ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA

Report Date:

1997-09-01

Pagination or Media Count:

5.0

Abstract:

We have developed an anesthetized microswine model of hypoxemic hypothermia and rewarming for testing prophylaxes and treatments. The respiratory stimulant almitrine bismesylate ALM was considered as a potential field expedient therapy for hypoxemic hypothermia. Preliminary experiments demonstrated that five consecutive 100 micrograms.kg-1 ALM intravenous 4 doses given to normothermic microswine 3-4 min apart increased minute ventilation from an average of 3.4 L.min-1 to 4.5 L.min-1 n 2. However, when either a single 4 ALM dose of 150 micrograms.kg-1 n 1 or three consecutive 100 micrograms.kg-1 4 doses given 15 min apart n 1 to hypoxemic hypothermic microswine with a mean esophageal temperature Tes 28.8 deg C, and a mean arterial O2 partial pressure PaO2 49 mmHg, the hypoxemia was potentiated mean PaO2 32 mmHg and respiratory arrest ensued. Other experiments using continuous ALM iv infusion 1.0 micrograms.kg-1.min-1 in hypoxemic hypo thermic microswine n 6, Tes - 0.5, PaO2 55.4 - 12.9 did not demonstrate significant p less than or equal 0.05 cardiorespiratory differences ventilation, heart rate, blood pressure, blood gases when compared to hypoxemic hypothermic controls n 6, Tes 30.7 - 0.5, PaO2 53.3 - 13.6. These results suggest that high dose 4 bolus administration of ALM is not indicated as a potential field expedient therapy for hypoxemic hypothermia, while further work is required to assess the potential efficacy of other continuous low dose iv infusion regimens.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE