Interfacial Culprits: Targetting Proteins of Byssal Adhesion
Final rept. 8 Jan 93, 30 Sep 96
DELAWARE UNIV NEWARK COLL OF MARINE STUDIES
Pagination or Media Count:
Marine mussels Mytilus form permanent adhesive bonds with hard surfaces in their environment. The adhesive plaques of the byssus are situated in closest proximity with the bonded foreign surface. Of the four proteins known to be present in byssal plaques, we have isolated, characterized, and cloned several variants of Mefp-3. These are small basic proteins with two prominent post-translational modifications, 3, 4-dihydroxyphenylalanine and 4- hydroxyarginine. Laser desorption studies of byssal plaques indicate Mefp-3s to occur at or near the interface.
- Genetic Engineering and Molecular Biology