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Breast Cancer Following Hodgkins Disease: Risk Factors and Intervention.

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Annual rept. 1 Jul 96-30 Jun 97,

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We conducted a study to evaluate the role of genetic predisposition as measured by family history of cancer in the development of breast cancer among the Late Effect Study Group cohort of survivors of Hodgkins disease in childhood. Of 17 women with secondary breast cancer identified in this cohort, 13 probands 76 or their surviving next of kin were available for construction of pedigrees. The median age at diagnosis of Hodgkins disease for these patients was 13 years and that for breast cancer was 34 years. Nineteen family members were reported to have experienced cancer among the 180 first- and second-degree relatives total follow-up of 9,351 person-years. Overall, there was a significantly decreased risk of cancer among the family members SlR0.6, 95 Cl, 0.4-0.9. Breast cancer was reported in three family members median age at diagnosis, 59.5 years, and there was no excess of breast cancer when compared to the general population. In an expanded assessment of the 13 cases with breast cancer developing at a very young age following treatment for Hodgkins disease, we failed to demonstrate any evidence of familial aggregation of cancer breast or otherwise among family members. The influence of biomarkers of genetic susceptibility need to be explored in order to identify high risk populations.

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  • Anatomy and Physiology
  • Medicine and Medical Research

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