Interactions of HIV-1 and HIV-2 in West Africa.
Midterm rept. 15 Nov 94-14 Jun 97
HARVARD COLL CAMBRIDGE MA
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We have demonstrated in populations of HIV-2 and HIV-1 infected individuals that these related viruses have distinct biologic properties. We have shown over a 12 year period the differences in HIV-2 and HIV-1 incidence and prevalence where HIV-2 appears to be less transmissible by heterosexual sex. In natural history studies we have shown significant differences in the progression to AIDS, where HIV-2 behaved as a less pathogenic virus. This led to the hypothesis that it might protect individuals from subsequent HIV-1 infection, which was shown in our recent studies. In preparation for future vaccine cohorts, we have characterized the HIV-1 subtypes in our seroconverting women and demonstrated differences in their progression to AIDS, with A subtypes showing a longer disease free incubation period compared to subtypes C,D, and G. Immunologic studies of these women have demonstrated that they are capable of recognizing subtype B targets, suggesting that vaccines based on subtype B could be broadly protective.
- Medicine and Medical Research