Yeast Genetics for Delineating Bax/Bc1 Pathway of Cell Death Regulation.
Annual rept. 1 Jul 96-30 Jun 97,
BURNHAM INST LA JOLLA CA
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Two novel human genes were cloned that inhibit cell death and that therefore may contribute to breast cancer by preventing the normal cell turnover that is essential for keeping overall numbers of cells in the mammary gland within physiologically appropriate ranges. These genes suppress the pro-death activity of a protein called Bax. The Bax protein was shown previously to be present in normal mammary tissue but reduced or absent in one-third of breast cancers, in association with poor patient responses to chemotherapy and shorter overall survival. The cloning of these two new genes, termed Bl-1 and Bl-2 for Bax-inhibitors 1 and 2, may provide insights into how to restore the function of Bax in breast cancer which has reduced levels of this cell death promoting protein.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research