Accession Number:

ADA327924

Title:

Vitamin D3 Analogues with Low Vitamin D Receptor Binding Affinity Regulate Chondrocyte Proliferation, Proteoglycan Synthesis, and Protein Kinase C Activity

Descriptive Note:

Master's thesis

Corporate Author:

AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH

Personal Author(s):

Report Date:

1997-07-11

Pagination or Media Count:

69.0

Abstract:

The purpose of the study was to determine the genomic and nongenomic mechanism of action of various analogues of vitamin D on resting zone RC and growth zone GC rat costochondral chondrocyte differentiation and proliferation in vitro. This study is intended to provide insight into how modifications of the A-ring and other structural modifications of vitamin D molecule affect the biological activity of these secosteroids.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE