Accession Number:
ADA327148
Title:
Regulation of Retinoid Responsiveness in Mammary Carcinoma Cells.
Descriptive Note:
Annual rept. 1 Sep 95-31 Aug 96,
Corporate Author:
COLUMBIA UNIV NEW YORK
Personal Author(s):
Report Date:
1996-09-01
Pagination or Media Count:
18.0
Abstract:
The data presented in this annual report support our hypothesis for a mechanism of retinoid-induced growth arrest of human breast cancer cells. Specifically, we believe that retinoids inhibit human breast cancer cell proliferation by inducing a state of functional mitogen deprivation. Kinetic and quantitative changes in cell cycle progression and gene expression following retinoic acid treatment of the estrogen dependent, T-47D breast cancer cell line, are consistent with retinoic acid inducing a block in the treated cells ability to respond to external mitogenic signals.
Descriptors:
Subject Categories:
- Biochemistry
- Genetic Engineering and Molecular Biology
- Anatomy and Physiology
- Medicine and Medical Research