Accession Number:

ADA327148

Title:

Regulation of Retinoid Responsiveness in Mammary Carcinoma Cells.

Descriptive Note:

Annual rept. 1 Sep 95-31 Aug 96,

Corporate Author:

COLUMBIA UNIV NEW YORK

Personal Author(s):

Report Date:

1996-09-01

Pagination or Media Count:

18.0

Abstract:

The data presented in this annual report support our hypothesis for a mechanism of retinoid-induced growth arrest of human breast cancer cells. Specifically, we believe that retinoids inhibit human breast cancer cell proliferation by inducing a state of functional mitogen deprivation. Kinetic and quantitative changes in cell cycle progression and gene expression following retinoic acid treatment of the estrogen dependent, T-47D breast cancer cell line, are consistent with retinoic acid inducing a block in the treated cells ability to respond to external mitogenic signals.

Subject Categories:

  • Biochemistry
  • Genetic Engineering and Molecular Biology
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE