Role of Tumor Collagenase Stimulating Factor in Breast Cancer Invasion and Metastasis.
Annual rept. 1 Dec 95-30 Nov 96,
STATE UNIV OF NEW YORK AT STONY BROOK
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EMMPRIN TCSF is a plasma membrane glycoprotein that is present on the surface of breast cancer cells, and is responsible, in part, for the elevated levels of MMPs in peritumoral fibroblasts and endothelial cells. EMMPRIN requires post-translational processing glycosylation for its ability to stimulate production of MMPs in target fibroblasts. Transfection of EMMPRIN cDNA into CHO cells resulted in the production of a glycosylated functional protein of similar molecular weight to native EMMPRIN 58 kDa that was localized to the plasma membrane. EMMPRIN mRNA is expressed in benign and malignant human mammary ducts and acini to a much greater degree than in normal breast ducts. Immunohistochemical approaches, however, have indicated that EMMPRIN is also present in normal breast ducts and some other epithelial structures.
- Medicine and Medical Research