Transforming Growth Factor-beta Receptors in Human Breast Cancer.
Annual rept. 1 May 96-30 Apr 97,
YALE UNIV NEW HAVEN CT SCHOOL OF MEDICINE
Pagination or Media Count:
This project addresses three fundamental research issues. The first question is whether or not molecular lesions of the genes involved in the TGFB signaling pathway contribute to the origin andor progression of breast cancer. We expect changes in these genes to be relatively late events, perhaps characteristic of metastatic cancer. Secondly, we propose to determine how molecular lesions in the TGFB receptor andor Smad genes affect receptor function, and how they might play a role in the development andor progression of breast cancer. Thirdly, we intend to examine the question whether genetic lesions in TGFB receptor andor Smad genes are able to predict the outcome of patients with breast cancer. Because the anti-tumor effects of anti-estrogens such as tamoxifen are thought to be mediated by the auto-and paracrine induction of TGFB, we wish to test the hypothesis that resistance of hormone-receptor positive cancers to tamoxifen is the result of inactivation of TGFB pathway genes.
- Genetic Engineering and Molecular Biology
- Anatomy and Physiology
- Medicine and Medical Research