Accession Number:

ADA327101

Title:

Initiation of Breast Cancer by Endogenous Estrogens: Mechanism and Prevention.

Descriptive Note:

Final rept. 1 Aug 94-31 Jan 97,

Corporate Author:

CORNELL UNIV MEDICAL CENTER NEW YORK

Personal Author(s):

• Fishman, Jack

Report Date:

1997-03-01

Pagination or Media Count:

36.0

Abstract:

Both endogenous and environmental factors are thought to contribute to cancer of the breast. Among these, estrogens have attracted intense interest for decades, but the mechanisms by which this class of hormone mediate normal and neoplastic growth have remained obscure. We provide in vitro data to support the hypothesis that 16 alpha-hydroxyestrone is unique among estrogens with regard to its transforming properties in mammary cells.

Descriptors:

• *PREVENTION
• *ESTROGENS
• *BREAST CANCER
• HORMONES
• ENVIRONMENTS
• NEOPLASMS
• IN VITRO ANALYSIS
• CELLS(BIOLOGY)
• GENETICS
• MAMMARY GLANDS
• GROWTH(PHYSIOLOGY)

Subject Categories:

• Biochemistry
• Genetic Engineering and Molecular Biology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE