Accession Number:

ADA327087

Title:

Cell-Matrix Interactions in Breast Carcinoma Invasion.

Descriptive Note:

Annual rept. 15 Dec 95-14 Dec 96,

Corporate Author:

NEW YORK UNIV MEDICAL CENTER NY

Personal Author(s):

Report Date:

1997-03-01

Pagination or Media Count:

12.0

Abstract:

Transgenic mice carrying an activated form of the N-ras oncogene under the control of the Mammary Tumor Virus Long Terminal Repeat promoter developed mammary carcinomas with a high frequency during the first few months of their life. The alpha 6 beta 4 and, to a minor extent, the alpha 2 beta 1 integrin were found to be upregulated and diffusely distributed at the tumor cell surface in the primary lesions of these mice.

Subject Categories:

  • Biochemistry
  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE