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Statistical Genetics Methods for Localizing Multiple Breast Cancer Genes.
Annual rept. 1 Sep 95-31 Aug 96,
COLUMBIA UNIV NEW YORK
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The first breast cancer gene, BRCA1, was localized in 1990. Now, a second breast cancer gene is known on chromosome 13 yet many breast cancer families show absence of linkage to either of these genes. Thus, investigators are searching to find additional genes responsible for familial breast cancer. These genes are expected to be associated particularly with late onset breast cancer while BRCA1 occurs primarily in early onset disease. One of the problems with linkage analysis of late onset diseases is that parents may be unavailable. Thus, in affected sib pair analysis a widely used nonparametric linkage analysis technique, there is no way that errors can be detected through mendelian inconsistencies. In other words, the purported siblings may not be sibs but, for example, half-sibs or unrelated individuals. A method was developed and implemented in a computer program to screen for non-sibs by statistical means. The results show that its application greatly increases power of affected sib pair linkage analysis.
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