Accession Number:

ADA326012

Title:

Role of Matrix Metalloproteinases and Their Tissue Inhibitors in Human Breast Adenocarcinoma.

Descriptive Note:

Annual rept. 1 Sep 95-31 Aug 96,

Corporate Author:

MIAMI UNIV FL

Personal Author(s):

• Gunja-Smith, Zeenat

Report Date:

1996-09-01

Pagination or Media Count:

54.0

Abstract:

The overall objective of this research is to explore the role of matrix metalloproteinases MMPs and the tissue inhibitors of metal- loproteinases TIMPs in the invasive and metastatic processes of human breast tumors. The hypothesis to be tested is that an imbalance arises through normal or elevated production of MMPs accompanied by a diminished production of inhibitory TIMPs. Metastasis of an initially localized tumor to vital organs is the dominant cause of cancer related deaths.

Descriptors:

• *TISSUES(BIOLOGY)
• *ENZYMES
• *BREAST CANCER
• EPITHELIUM
• HUMANS
• PROTEINS
• NEOPLASMS
• INHIBITORS
• MAMMARY GLANDS
• METASTASIS

Subject Categories:

• Biochemistry
• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE