Accession Number:

ADA324577

Title:

Serotonin and the Scientific Basis of Anti-Emetic Therapy,

Descriptive Note:

Corporate Author:

OXFORD UNIV (UNITED KINGDOM) RADCLIFFE INFIRMARY

Report Date:

1995-12-01

Pagination or Media Count:

283.0

Abstract:

Emesis research a concise history of the critical concepts and experiments The physiology of emesis induced by anti-cancer therapy The discovery of selective 5-hydroxytryptamine-3 5-HT3 receptor antagonists The clinical approach to chemotherapy-induced emesis How do toxic emetic stimuli cause 5-HT release in the gut and brain The role of free radicals and nitric oxide in the induction of emesis The pharmacology of 5-HT release from enterochromaffin cells The vagal afferent response to 5-HT and cisplatin The electrophysiology of vagal and recombinant 5-HT3 receptors 5-HT3 receptors in the dorsal vagal complex Where do 5-HT3 receptor antagonists act as anti-emetics 5-HT3 receptor antagonists and radiation-induced emesis preclinical data Clinical evidence for 5-HT3 receptor antagonist efficacy in radiation-induced emesis Clinical evidence for the involvement of serotonin in acute cytotoxic-induced emesis What is the involvement of 5-HT3 receptors in postoperative nausea and vomiting Preclinical differences in 5-HT3 receptor antagonist characteristics Are there any true clinical differences hetween 5-HT3 receptor antagonists Limitations in the efficacy of 5-HT3 receptor antagonists Does 5-HT play a role in the delayed phase of cisplatin-induced emesis 5-HT4 receptor involvement in emesis Are 5-HT3 receptor effects on gastrointestinal motility relevant to anti-emesis Opioid receptor involvement in emesis and anti-emesis

Subject Categories:

  • Anatomy and Physiology
  • Pharmacology
  • Organic Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE