Inhalation Uptake and Metabolism of Iodohalogenated Compounds, CF3I, C6F13I, and C3F7I.
Interim rept. Jun 93-Mar 95,
MANTECH ENVIRONMENTAL TECHNOLOGY INC DAYTON OH
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The purpose of this study was to measure the tissue to air partition coefficients and to describe the uptake and distribution kinetics of iodohalogenated compounds iodotrifluoromethane CF3I, perfluorohexyl iodide C6F13I and l-iodoheptafluoropropane C3F7l via closed chamber recirculating gas uptake methods. Inhalation pharmacokinetics for all chemicals were determined experimentally in Fischer-344 F-344 male rats. A physiologically based pharmacokinetic PBPK model was used to describe mathematically the disposition and metabolism of the chemicals employing chemical-specific parameters and apparent whole-body metabolic constants calculated from these expenments