Dermal Toxicity Evaluation of Neutralized Chemical Agent Identification Sets (CAIS) with an Overview of the Dermal Toxicity of Vesicant Agents and their Degradation Products.
Final rept. Jan-Sep 95,
EDGEWOOD RESEARCH DEVELOPMENT AND ENGINEERING CENTER ABERDEEN PROVING GROUNDMD
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Acute dermal toxicity limit test and skin irritation studies were conducted in New Zealand white rabbits to ascertain the systemic toxicity and skin-injury potential of chemically-neutralized Chemical Agent Identification Sets CAIS. Studies also included the assessment of oxidantsolvent systems and solvent induced toxicity. The toxicity limit test consisted of a 24-hr occluded exposure to 1.0 mlkg of test article. Dermal irritation studies were based on a 4-hr occluded exposure to 0.5 ml of test article. Chemical neutralization of CAIS resulted in complex product solutions wastestreams containing ppm levels of agent and an array of degradation products. Findings from the skin irritation testing of wastestreams and oxidantsolvent systems indicate that wastestream-induced skin effects edema and erythema were equivalent to or less in severity than the skin effects produced by exposure to oxidantsolvent systems. Systemic effects were not observed in 45 wastestream-exposed groups however, 25 wastestream-treated groups exhibited systemic effects. Lethality was noted in only 15 wastestream-treated groups. Limit test data indicate that agents HD, HN, or L were destroyed by reaction with oxidant to less toxic materials.
- Anatomy and Physiology
- Chemical, Biological and Radiological Warfare