Dendritic Cell Vaccine Therapy for Breast Cancer Micro-Metastasis.
Final rept. 8 Aug 94-7 Aug 96,
ALABAMA UNIV UNIVERSITY
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This project is studying the development of dendritic cell vaccines for immune therapy of breast cancer. The underlying reason for failure to cure patients diagnosed with breast cancer is the presence of micro-metastasis in approximately one-third of breast cancer patients. The stimulation of antitumor immune responses represents one of the most effective ways to treat low tumor burdens that are microscopically or clinically occult. The objective of our proposal is to determine whether novel dendritic cell DC vaccines containing a human tumor-associated antigen carcinoembryonic antigen can induce systemic immunity and eradication of micro-metastasis in a synergetic murine breast cancer model which expresses human CEA. The feasibility and efficacy of this CEA vaccine strategy would be applicable to other putative tumor-specific or associated tumor antigens.
- Medicine and Medical Research