Genetic Counseling Using BRCAl-Linked Markers,
Annual rept. 1 Sep 95-31 Aug 96,
CREIGHTON UNIV OMAHA NE SCHOOL OF MEDICINE
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Since the initiation of this study, we have provided 14 BRCA1 and 2 BRCA2 families with information sessions held at various geographic areas of the United States. These sessions included intensive education about the natural history, genetics, surveillance and management of the hereditary breastovarian cancer syndrome. The limitations and advantages of DNA testing were discussed stressing potential liabilities such as fear, anxiety, and insurance and employer discrimination. Genetic counseling was provided again prior to releasing DNA test results to 181 individuals who wanted to know their mutation status. Reasons given by them for being tested were concern about their siblings and children, and about screening andor prophylactic surgery. Seventy-six percent who were BRCA1 mutation positive would give prophylactic cophorectomy serious consideration 35 would consider prophylactic masectomy. No significant increase in depression was noted. Eighty-one percent who were negative for BRCA1 were extremely happy and relieved. A small subset 4 experienced survivor guilt. We continue to learn about genetic counseling as a result of this experience and to accumulate information relevant to its psychological components through collaboration with Caryn Lerman, Ph.D. BRCAl and BRCA2 mutations have been identified in an additional 27 families and will be available for future study.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research