Studies for the Prevention and Treatment of Malaria, Leishmania, and Other Emerging Infectious Diseases in Brazil.
Annual rept. 1 Aug 95-31 Jul 96,
FUNDACAO CECILIANO ABEL DE ALMEIDA VITORIA (BRAZIL)
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Advances in diagnosis and treatment of disease include understanding the behavior and susceptibilities of the vector, the parasite virus, or bacteria, and the host. Genetic studies have shown differences at the molecular level in parasites which may aid rapid diagnosis and allow prognosis limiting toxic drug therapy. Ongoing trials of toxicity and effectiveness in the first oral drug for visceral leishmaniasis WR6O26 include two cohorts where neither adequate efficacy nor significant toxicity has been determined. A third cohort at a higher dose interval will be important to determine whether higher doses will increase the cure rate without increasing toxicity. Malaria research has allowed the development in Rio of free-mating colonies of 2 Anopheles species and ongoing collection and behavioral studies of infecting mosquitoes. High P. falciparum drug resistance rates have been determined necessitating the development and validity testing of rapid screening assays and insect repellents. Surveillance and study I of Dengue, Leptospirosis and Hepatitis E continues.
- Medicine and Medical Research