Nature and Prognostic Significance of Alterations in the DCC and E-Cadherin Genes in Breast Cancer.
Annual rept. 15 Jul 95-14 Jun 96,
YALE UNIV NEW HAVEN CT
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In the original application, three technical objectives were proposed with the goal of understanding the role of the adhesion molecules DCC and E-cadherin in breast cancer. The initial task focused on use of LOH to assist in confirming that these adhesion molecules are important in the pathogenesis of breast cancer. Ultimately, the long term goals were to apply the findings of these studies to improving the diagnosis and management of breast cancer.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research