Program for Critical Technologies in Breast Oncology.
Annual rept. 1 Jul 95-30 Jun 96,
YALE UNIV NEW HAVEN CT SCHOOL OF MEDICINE
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The description of work accomplished is presented under five headings 1 collection of samples 2 establishment of a database 3 preparation and distribution of samples 4 development of assays relevant to breast cancer and 5 supplemental activities. 1 We have established protocols for collection and utilization of tissues at Yale and at fourteen off-site hospitals. We also have initiated or obtained IRB approval in all sites, and have trainedare training technical personnel. 2 We are implementing the database proposed in the original application. In addition, we have initiated a data exchange program with the Yale Cancer Center, Yale-New Haven Hospital, and the Yale Tumor Registry. 3 We have collected in the past year a total of 3754 samples of breast tissues from 1016 cases. We have distributed 8335 tissue-derived products to investigators. 4 We have developed assays to assess the status of pS3, Ki-ras, cyclin D-l PRAD, neuerbB-2, microsatellite variability, pl6 MTS, AP-2, human Disheveled hDsh, phospho-neuerbB-2 p185, and others. 5 We participate in a working group addressing the ethical and legal issues raised by storing samples linked to medical information concerning individual patients.
- Medicine and Medical Research