Accession Number:

ADA314205

Title:

New Approaches to the Labeling of Estrogens Useful for PET.

Descriptive Note:

Annual rept. 1 Jun 95-31 May 96,

Corporate Author:

WASHINGTON UNIV ST LOUIS MO

Report Date:

1996-07-01

Pagination or Media Count:

17.0

Abstract:

Estrogen receptor positive breast tumors are evaluated by positron emission tomography PET utilizing radiolabeled estrogen ligands. This imaging technique is used to predict the tumors response to therapy and to follow the progress of disease. Desiring to find new estrogens with high binding affinity for the estrogen receptor, we synthesized 16 alpha-methoxy estradiol. This compound previously had not been isolated nor its binding affinity measured. Characterization has been achieved by 1H and 13C NMR as well as by low resolution and high resolution mass spectrometry. The synthesis was achieved by applying the chemistry of methyl hypofluorite to steroids. Optimization of reaction conditions has laid the foundation for future radiolabeling studies. Binding affinity of this compound for the estrogen receptor is currently being determined.

Subject Categories:

  • Medicine and Medical Research
  • Radiation and Nuclear Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE