Accession Number:

ADA312794

Title:

Evaluation of the Mechanism of Immunosuppression and Calcium Homeostasis by an Immunosuppressive Trauma Peptide.

Descriptive Note:

Final rept. 1 Jun 94-31 May 95,

Corporate Author:

CALIFORNIA UNIV MEDICAL CENTER SAN DIEGO

Personal Author(s):

Report Date:

1995-11-01

Pagination or Media Count:

5.0

Abstract:

T-Cell suppressive factors TSF are thought to suppress host immunity and contribute to the development of sepsis. During the past year, we have investigated the relative roles of prostaglandin E2 PGE2, Interleukin 4 ITh-4, Interleukin 10 IL-lO, and transforming growth factor TGFE1 as immunosuppressive factors in our rabbit endotoxemia model. Endotoxemia suppresses in. vivo cell mediated immune function and increased PGE2, IL-4, IL-lO, and TGF levels are measurable. Serum from these animals following endotoxemia suppresses T-cell proliferation and ITh-4, ITh-lO, TGF, and PGE2 had TSF activities of 530, 102, 12, and .37 Ung. TGF, IL-lO, and TTh-4, contributed 37, 32, and 14 Uml to a total serum TSF activity of 614 Uml, while PGE2 contributed only .007 Uml. These results show that TGF1, IL-lO, IL-4, and other uncharacterized factors, are potent T-cell suppressors following rabbits. PGE is df much less Significance.

Subject Categories:

  • Pharmacology
  • Organic Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE