Hepatic Toxicity of Perfluorocarboxylic Acids.
Final technical rept. 1 Jan 92-31 May 96,
WRIGHT STATE UNIV DAYTON OH
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This AASERF grant has provided support for two graduate students in the Biomedical Sciences Ph.D. Program at Wright State University, Dayton, OH. A Ph.D. degree was conferred in 1994 to C. Goecke- Flora, while the other student, M. Adinehzadeh, currently continues in the program. These students were provided a stipend, a nominal budget for research supplies, and travel funds which enabled them to present their data at national scientific conferences. The students utilized nuclear magnetic resonance techniques in toxicology research concerning peroxisome proliferators PPs. This work has culminated in five publications and eight published abstracts. PPs are a diverse series of chemicals with various commercial and Air Force applicabilities. Perfluorocarboxylic acids and various other halocarbons, for instance, are useful as nonflammable solvents, lubricants, and degreasers. Our research has shown that the berfluorocarboxylic acids are not metabolized, yet they produce significant effects on liver carbohydrate and phospholipid metabolism. Perfluorodecanoic acid, in particular, enhances the biosynthesis of liver phosphatidylcholine PC, causes a significant increase in phosphocholine and diacylglycerol, and inhibits the major de novo pathway for the synthesis of PC. These data suggest that other pathways of phospholipid metabolism are activated following treatment with these PPs. Such effects may alter cellular signaling processes and help to explain the hepatotoxicity and carcinogenicity associated with these compounds.
- *NUCLEAR MAGNETIC RESONANCE
- *HALOGENATED HYDROCARBONS
- AIR FORCE
- TOXIC AGENTS
- FIRE RESISTANCE
- Atomic and Molecular Physics and Spectroscopy