Sol-Gel Based Electrochemical Biosensors.
Technical rept. 1 Jun 95-31 May 96,
CALIFORNIA UNIV LOS ANGELES DEPT OF MATERIALS SCIENCE AND ENGINEERING
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This work is based on the use of the sol-gel process to encapsulate biomolecules in a porous silicate matrix. The porosity of the matrix is such that small molecules and ions can readily diffuse into the materials while the much larger proteins remain trapped in the silicate network. Using this approach, it is possible to develop new types of solid state sensors which use the specificity of enzymes and proteins for binding of substrates or related molecules. The objective of our initial work has been to obtain electron transport from the redox center of an encapsulated enzyme making use of redox-active molecules or mediators so as to measure the electrochemical response of the doped sol-gel to an external analyte.
- Inorganic Chemistry
- Solid State Physics
- Laminates and Composite Materials