Vitamin D and Breast Cancer.
Annual rept. 1 Jul 94-31 Dec 95,
STANFORD UNIV CA
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The objective of the proposed data analysis project is to assess whether high exposure to vitamin D from sunlight exposure, diet, and dietary supplements is associated with reduced breast cancer risk. We will perform a retrospective cohort analysis based on data provided by the cohort of women aged 25 to 74 years who participated in the first National Health and Nutrition Examination Survey NHANES I from 1971 to 1975 and who were followed-up in the NHANES I Epidemiologic Follow-Up Studies conducted in 1982-84 1986, and 1987. The average follow-up period was 15 years, during which 190 newly diagnosed breast cancers occurred. For each vitamin D-related exposure measure, we will estimate the incidence of breast cancer among exposed women and unexposed women, and we will estimate the relative risk associated with these exposure variables using the Cox proportional hazards model and Poisson regression, adjusting for potentially confounding variables. This data analysis project is a cost-effective way to explore a new hypothesis addressing potentially modifiable risk factors for breast cancer.
- Medicine and Medical Research
- Food, Food Service and Nutrition