Evaluation of Chemotherapeutic Agents Against Malaria; Drugs, Diet, and Biological Response Modifiers.
Annual rept. 5 Oct 91-4 Oct 92,
MIAMI UNIV FL
Pagination or Media Count:
In the primary blood schizonticidal test 1,043 compounds were evaluated and 186 exhibited antimalarial activity. In the Thompson Test 41 experiments were performed to access suppressive and curative activity against drug-sensitive lines or lines resistant to chloroquine, mefloquine, halofantrine, quinine, WR238605, pyrimethamine, tetraoxane WR163577, and WR99210. Twenty-two transdermal tests were performed with several artemisinin analogs. Dihydroartemisinin was the most active compound. Louderbacks Sterilizing Medium was tested against drug-sensitive parasites and artemisinin-resistant ones. Special tests with trioxanes, beta-artemether, and trifluralin were done. Sixteen antioxidant experiments were done, which included testing wR238605 and tetraoxane BM11681 in mice primed for oxidative stress. Mice were cured of cerebral malaria by altering the oxidative status of the hosts RBCs. Surviving mice were rechallenged to evaluate the curative activity of drugs.
- Medicine and Medical Research