Influence of Large Volume Phlebotomy on Compensatory Tracking Performance in Rhesus Monkeys.
Final rept. Jan-Dec 95,
ARMSTRONG LAB BROOKS AFB TX OCCUPATIONAL AND ENVIRONMENTAL HEALTH DIRECTORATE
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In the biomedical research community, veterinarians charged with the clinical care of nonhuman primates occasionally are called upon to make judgments on the issue of blood volumes, blood sampling criteria, and the effects of phlebotomy on research results. The clinician must balance on a fine line when allowing investigators to perform either frequent small volume phlebotomies, or single large volume phlebotomies. Some large primate colonies allow 10 m1kg of whole blood to be removed as single withdrawals no more often than once per month, while other institutional policies dictate smaller volumes and less frequent sampling intervals. Since it has already been proven that rhesus monkeys survive single, large volume phlebotomies without adverse effects, a study was designed to determine the effects of such large volume phlebotomy on the performance of a demanding sensorimotor task. This task, the Primate Equilibrium Platform PEP, is sensitive to changes in central nervous system sensorimotor integration, but does not necessarily involve complex cognitive functions. It was found that PEP was unaffected after single, large volume 10 m1kg phlebotomy in rhesus monkeys.
- Anatomy and Physiology