Genetic Toxicity Evaluation of 1,3,3-Trinitroazetidine. Volume 2. Results of Mouse Bone Marrow Micronucleus Test.
Final rept. Jul-11 Dec 92,
TOXIKON CORP WOBURN MA
Pagination or Media Count:
1 3,3-Trinitroazetidine TNAZ was dissolved in corn oil and injected intraperitonealy daily into albino Swiss mice for 3 days at doses of 40, 20, 10, 5, and 1 mgkg. TNAZ did not induce an increased number of micronucleated cells and is considered to have a negative response. The positive control substance, mitomycin C, induced a statistically significant number of micronucleated cells, whereas the negative control substance corn oil, did not induce increased number of micronucleated cells in the maturing erythrocytes of mouse bone marrow cells. Therefore, TNAZ is considered non-mutagenic, under the test system and conditions employed in this study.
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