Accession Number:

ADA303835

Title:

Genetic Toxicity Evaluation of 1,3,3-Trinitroazetidine. Volume 2. Results of Mouse Bone Marrow Micronucleus Test.

Descriptive Note:

Final rept. Jul-11 Dec 92,

Corporate Author:

TOXIKON CORP WOBURN MA

Personal Author(s):

Report Date:

1994-02-01

Pagination or Media Count:

31.0

Abstract:

1 3,3-Trinitroazetidine TNAZ was dissolved in corn oil and injected intraperitonealy daily into albino Swiss mice for 3 days at doses of 40, 20, 10, 5, and 1 mgkg. TNAZ did not induce an increased number of micronucleated cells and is considered to have a negative response. The positive control substance, mitomycin C, induced a statistically significant number of micronucleated cells, whereas the negative control substance corn oil, did not induce increased number of micronucleated cells in the maturing erythrocytes of mouse bone marrow cells. Therefore, TNAZ is considered non-mutagenic, under the test system and conditions employed in this study.

Subject Categories:

  • Toxicology
  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE