Estrogen Metabolism in Breast Cancer Cases and Controls.
Annual rept. 1 Oct 94-30 Sep 95,
UNIVERSITY OF SOUTHERN CALIFORNIA LOS ANGELES SCHOOL OF MEDICINE
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It has been suggested that women who metabolize a larger proportion of their natural estrogen via the 16a-hydroxy pathway may be at significantly elevated risk of breast cancer compared to women who metabolize proportionally more estrogen via the 2-hydroxy pathway. This study evaluates whether the ratios of 16a-OHEl to 2-OHEl are higher in urine of postmenopausal breast cancer cases than in controls and whether the ratio is elevated in cases independent of total urinary estrone E1, estradiol E2 and estriol E3. Early morning urine samples are collected from 100 breast cancer cases and 100 controls who are participating in an ongoing case-control study of breast cancer at our institution. Five estrogen metabolites in urine are determined 16a-OHEl, 2-OHEl, El, E2 and E3 conjugates. The data collection is in progress.
- Medicine and Medical Research
- Anatomy and Physiology