The Role of P53 in Human Breast Cancer.
Annual rept. 1 Sep 94-31 Aug 95,
TEXAS UNIV AT DALLAS
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The technical objectives of this project are to transfect mutant p53s into normal human mammary epithelial cells obtained from different donors and to isolate clones. The clones will be characterized for extension of lifespan and immortalization in cell culture. It will also be determined if expression of any of the mutant p53s provide a growth advantage to breast epithelial cells prior to immortalization. An additional objective is to determine in breast epithelial cells immortalized and expressing mutant p53 if expression of the mutant p53 is necessary for the maintenance of growth. Finally, downstream genomic targets of pS3 that may be important in the development and progression of breast cancer will be determined.
- Medicine and Medical Research
- Anatomy and Physiology