Hormones and Breast Cancer.
Annual rept. 30 Sep 94-29 Sep 95,
UNIVERSITY OF SOUTHERN CALIFORNIA LOS ANGELES SCHOOL OF MEDICINE
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Grant consists of separate projects The first aims at assessing the association between lifestyle factors hormone use and breast cancer the second aims at elucidating the role of estrogen metabolism in the development of breast cancer the third aims at understanding the relation of female hormone levels to changes in mammographic densities, a possible intermediate endpoint in cancer prevention studies. The first project uses data from a case-control study of Asian-American immigrants where the relative risks associated with oral contraceptive use will be assessed. The second project consists of two studies a case-control study of postmenopausal breast cancer patients and a case-control study of premenopausal women with high and normal risk of breast cancer. Urinary estrogen metabolites will be compared to test the hypothesis that the 16-alpha pathway of estrone metabolism is associated with breast cancer risk. Project 3 is 2 studies of hormone induced changes in mammographic densities. These studies will test the hypothesis that reducing serum estrogen and progesterone levels reduces mammographic densities.
- Medicine and Medical Research
- Anatomy and Physiology