The Role of IGFs in the Dietary Lipid Regulation of Breast Cancer.
Annual rept. 30 Sep 94-29 Sep 95,
ROCHESTER UNIV NY
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The overall objective of this study is to improve our understanding of the lipid dependent biochemical processes involved in breast cancer development, in order to develop more effective diet based cancer prevention strategies. We have shown previously that alterations in dietary lipid can significantly influence the development of mammary tumors. The experiments in this project are designed to explore to what extent, if any, dietary lipid manipulations may influence the expression of these lOF receptors and their binding proteins in two different mammary tumor models. During the initial part of the first year of this grant we hired the personnel, and developed the protocols and techniques to be used throughout the study. Later, we transplanted R- 323OAC mammary tumors into F-344 rats maintained on four diets of different lipid composition. We also attempted to induce mammary tumors using NMU in similar diet treated animals. The tissues from these animals have been collected, and are now undergoing biochemical analysis.
- Medicine and Medical Research
- Anatomy and Physiology