The Tumor Suppressor Protein p53 and its Physiological Splicing Variant p53as in a Mouse Mammary Cancer Model.
Annual rept. 1 Oct 94-30 Sep 95,
HEALTH RESEARCH INC BUFFALO NY
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The proposed studies seek to explore cellular and molecular aspects of p53 function that may contribute to the development and progression of breast cancer. The hypotheses are 1 that p53 and a novel physiological splicing variant, p53as, have distinct stability in cells, distinct expression during the cell cycle, and distinct associated proteins 2 that p53as has different specificity or affinity for DNA binding sequences than p53 and 3 that p53 and p53as mRNA and protein are differentially expressed in mouse mammary preneoplastic and neoplastic cells and tissues with implications for breast cancer detection, prognosis or treatment.
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