Biological Specimen Bank to Enhance Population Based Studies of Inherited Breast Cancer Genes.
Annual rept. 30 Sep 94-29 Sep 95,
DANA-FARBER CANCER INST BOSTON MA
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The technical objectives of this infrastructure enhancement project are to establish a population- based biological specimen and data bank on 225 women with invasive breast cancer, aged 35 and under. This new resource will be available to multiple investigators to identify and determine the frequency of inherited gene alterations in p53, BRCAl and additional inherited breast cancer susceptibility genes, and studies of gene-environmental interactions. Our cases will help provide the first estimates of germinal mutation frequency among the 90 percent of young patients who have no family history of breast cancer. Work is on schedule so that 225 young cases will be ascertained over 24 months through the tumor incidence registries in Connecticut, Massachusetts and 7 regions in California. Demographic, epidemiologic and family history data will be collected, paraffin-fixed tumor tissue retrieved, and a fresh blood specimen will be processed to produce genomic DNA, a plasma specimen, and viably frozen cells. A computerized file of the epidemiologic data and specimen data will be made accessible to all researchers via the Internet.
- Medicine and Medical Research
- Genetic Engineering and Molecular Biology