Regulation of Breast Cancer Invasion and Metastasis by Progestin and Antiprogestin.
Annual rept. 26 Sep 94-25 Sep 95,
LONG ISLAND JEWISH HOSPITAL NEW HYDE PARK NY
Pagination or Media Count:
It is known that breast cancer is dependent upon estrogenic hormones in about one-third of all clinical cases and can be inhibited by antiestrogenic antagonists. We are now hypothesizing that progestational hormones may also function as a stimulus for onset and progression of breast cancer and antiprogestin can interrupt these processes. The overall goals are to develop an in vivo model system for evaluating effects of progestins and antiprogestins on human breast tumor growth and metastasis. Using our recently established T47D-derived TKS-7 FOF-4 transfected metastatic model, we have initiated experiments designed to investigate the effects of progestational hormones and antiprogestin onapristone on the regulation of human breast cancer growth and metastasisin nude mice. In addition, we will attempt to identify mechanisms underlying these regulations. TKS-7 behaves like a hormone-independent but still hormone responsive phenotype in nude mouse. Progesterone significantly stimulates the tumor growth and this progesterone-induced growth stimulation can be inhibited by antiprogestin onapristone. Furthermore antiestrogen tomaxifen treatment enhances the progestational stimulation of tumor growth.
- Medicine and Medical Research
- Anatomy and Physiology