Accession Number:

ADA303030

Title:

Development of Recommended Test Method for Toxicological Assessment of Inhaled Combustion Products.

Descriptive Note:

Final rept.,

Corporate Author:

NATIONAL BUREAU OF STANDARDS GAITHERSBURG MD

Report Date:

1980-09-01

Pagination or Media Count:

63.0

Abstract:

The objective of the project supported by PRC was to develop a test method for measuring the toxicity of combustion products from polymeric materials including cellular plastics. The development of such a test procedure was considered an essential first step to determine the hazard to life when cellular plastics are involved in fire. As a result of this work, a test procedure was developed. It consists of 3 major elements 1 combustion system, 2 chemical analysis system and 3 animal exposure system. Two biological endpoints obtained from the exposure are 1 incapacitation in 30 minute exposure period, and 2 lethality in 30 minutes plus 14 days post exposure. The test apparatus has been evaluated to determine mixing rates and loss of reactive chemicals in the exposure chamber. In addition, a statistical evaluation of the experimental results demonstrated that order of incapacitation was independent of animal location. Evaluation of a limited number of different materials that produce different toxicological syndromes has demonstrated the utility of all 3 endpoints. Two natural polymers wood and wool and 2 synthetic materials modacrylic and PTFE have been studied in detail. In addition, preliminary data have been obtained on a flexible polyurethane foam GM-21.

Subject Categories:

  • Toxicology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE