Isolation of a Receptor for WNT/Wingless Growth Factors.
Annual rept. 1 Sep 94-31 Aug 95,
STANFORD UNIV CA
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The work done in this grant aims at elucidating the function of the Wnt signaling molecules in cancer. Wnt proteins are secreted and play important growth controlling roles, in particular in the mammary gland. They can act as oncogenes in mouse mammary tumors. The work is specifically aimed at identifying a receptor for Wnt proteins. The isolation of a receptor is critical to our understanding of normal growth control of the mammary gland. Using genetic and biochemical approaches we wish to identify and to clone the receptor for a Wnt gene product in Drosophila, called wingless. The receptor will be characterized and using the receptor gene, we will subsequently clone mammalian Wnt receptors by homology.
- Medicine and Medical Research