Accession Number:

ADA301699

Title:

Statistical Genetic Methods for Localizing Multiple Breast Cancer Genes.

Descriptive Note:

Annual rept. 1 Sep 94-31 Aug 95,

Corporate Author:

COLUMBIA UNIV NEW YORK

Personal Author(s):

Report Date:

1995-09-01

Pagination or Media Count:

8.0

Abstract:

Genetic risks are often computed as a single number a so-called point estimate under the assumption that all parameters involved in the calculation of the risk are known without error. In previous work, a method was developed to allow for variability in these parameters. Technically, by the use of the maximum likelihood method, a support interval approximate confidence interval is constructed for the risk. This method has been extended to incorporate age-dependent penetrances in the calculation of risk support intervals. As an empirical example, the support interval for the risk is calculated for a member of a published breast-ovarian cancer kindred.

Subject Categories:

  • Medicine and Medical Research
  • Genetic Engineering and Molecular Biology
  • Statistics and Probability

Distribution Statement:

APPROVED FOR PUBLIC RELEASE