Statistical Genetic Methods for Localizing Multiple Breast Cancer Genes.
Annual rept. 1 Sep 94-31 Aug 95,
COLUMBIA UNIV NEW YORK
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Genetic risks are often computed as a single number a so-called point estimate under the assumption that all parameters involved in the calculation of the risk are known without error. In previous work, a method was developed to allow for variability in these parameters. Technically, by the use of the maximum likelihood method, a support interval approximate confidence interval is constructed for the risk. This method has been extended to incorporate age-dependent penetrances in the calculation of risk support intervals. As an empirical example, the support interval for the risk is calculated for a member of a published breast-ovarian cancer kindred.
- Medicine and Medical Research
- Genetic Engineering and Molecular Biology
- Statistics and Probability