TGFa-myc Interactions in Mammary Tumorigenesis.
Annual rept. 1 Sep 94-31 Aug 95,
GEORGETOWN UNIV WASHINGTON DC
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This project sets out to establish in vivo, the basis for a dramatic cooperation between the C- myc oncogene and transforming growth factor a TGFa. These two genes are commonly amplified or overexpressed respectively in human breast cancer. We will use a novel bitransgenic model to overexpress the two genes in the mouse mammary gland. In addition, we will use mammary epithelial transplant procedure to establish whether this interaction can occur when TOFa and Myc interact in a paracrine fashion. Finally, the expression of several human breast cancer associated genes will be studied in tumors which arise. In the first year of study, we successfully established the timecourse, sex dependence, and organ preference for TOFa - Myc interactions in our system. In addition, we characterized the expression of both transgenes and the epidermal growth factor receptor in mammary and salivary tumors which arose.
- Anatomy and Physiology
- Medicine and Medical Research