PET-FDG Imaging in Metastatic Breast Cancer Treated with High Dose Chemotherapy and Stem Cell Support.
Annual rept. 1 Sep 94-31 Aug 95,
PENNSYLVANIA UNIV PHILADELPHIA
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The study is designed to assess the effectiveness of PET-FDG imaging in patients with metastatic breast cancer who are being treated with high dose chemotherapy and stem cell rescue. This study was to include a homogeneous group of patients entered on two studies PBT- 1 and Protocol UPCC 1192 for the treatment of breast cancer with high dose chemotherapy. We have amended our study by adding protocol UPCC 3195 as an additional source of patient accrual. The chemotherapy protocol 3195 is identical to the chemotherapy regimen used in PBT- 1, but with peripheral stem cell rescue. Until now, 5 patients have had their initial PET study before high dose chemotherapy. Two of these patients have normal or nearly normal studies, one patient has questionable right hilar uptake, one patient has diffuse bone marrow and splenic activity attributed to reactive bone marrow, but with active metastases in the dorsal spine. One patient has uptake in her right breast. These preliminary data indicate that PET can potentially predict therapeutic failures, although a larger sample and the follow-up studies will be necessary for confirmation.
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